Things that are difficult to say when you are drunk:
Indubitably
Innovative
Preliminary
Proliferation
Cinnamon

Things that are very difficult to say when you are drunk:
Specificity
British Constitution
Passive-aggressive disorder
Loquacious Transubstantiate

Things that are down right impossible when you are drunk:
"Thanks, but I don't want to have sex."
"Nope, no more booze for me."
"Sorry, but you're not really my type."
"Good evening officer, isn't it lovely out tonight."
"Oh, I just couldn't. No one wants to hear me sing."